Synovial expression of glucocorticoid receptor parallels fibroblast activation in patients with rheumatoid arthritis.

GR is overexpressed in the synovium of some RA patients in association with proinflammatory gene expression and activated sublining fibroblast status. Further studies should examine whether GR overexpression may act as a compensatory mechanism sensitizing synovial tissue to glucocorticoid action in RA.