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Migrating to Long-Read Sequencing for Clinical Routine BCR-ABL1 TKI Resistance Mutation Screening.

Wesley SchaalAdam AmeurUlla Olsson-StrömbergMonica HermansonLucia CavelierOla Spjuth
Published in: Cancer informatics (2022)
Long-read sequencing delivers results with higher sensitivity compared to Sanger sequencing and enables earlier detection of emerging TKI resistance mutations. The developed processes, analysis workflow, and software components lower barriers for adoption and could be extended to other applications.
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