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Taking the Analysis of Trial-Based Economic Evaluations to the Next Level: The Importance of Accounting for Clustering.

Mohamed El AliliJohanna M van DongenKeith S GoldfeldMartijn W HeymansMaurits W van TulderJudith E Bosmans
Published in: PharmacoEconomics (2021)
Although OLS produced similar cost-effectiveness outcomes, it substantially underestimated the amount of variation in the data compared with MLM. To prevent suboptimal conclusions and a possible waste of scarce resources, it is important to use MLM in trial-based economic evaluations when data are clustered.
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