Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation.

Nikoleta PavlakiAlexander FroeseWener LiKirstie A De JongBirgit GeertzHariharan SubramanianSanika MohagaonkarXiaojing LuoMario SchubertRobert WiegmannJean Piero MargariaAlessandra GhigoSusanne KämmererEmilio HirschAli El-ArmoucheKaomei Guan Viacheslav O Nikolaev

Published in: Cardiovascular research (2024)

Our data indicate that gene therapy with phosphodiesterases can prevent heart failure including associated cardiac remodeling and arrhythmias by restoring altered cAMP compartmentalization in functionally relevant subcellular microdomains.

Keyphrases

gene therapy
heart failure
left ventricular
binding protein
congenital heart disease
cardiac resynchronization therapy
acute heart failure
atrial fibrillation
big data
mouse model
deep learning
artificial intelligence
data analysis