Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial.
Yukihide KanemitsuKohei ShitaraJunki MizusawaTetsuya HamaguchiDai ShidaKoji KomoriSatoshi IkedaHitoshi OjimaHideyuki IkeAkio ShiomiJun WatanabeYasumasa TakiiTakashi YamaguchiKenji KatsumataMasaaki ItoJunji OkudaRyoji HyakudomiYasuhiro ShimadaHiroshi KatayamaHaruhiko Fukudanull nullPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Given that PTR followed by chemotherapy showed no survival benefit over chemotherapy alone, PTR should no longer be considered a standard of care for patients with CRC with asymptomatic primary tumors and synchronous unresectable metastases.