Supported Palladium-Catalyzed Tandem Synthesis of 2-(Alkylamino/amino)-3-arylquinazolin-4(3H)-ones Employing CO Source.

Herein, we demonstrated heterogeneous and recyclable polystyrene-supported palladium (Pd@PS) nanoparticles (NPs) catalyzed tandem addition and intramolecular aminocarbonylative cyclization approach for the synthesis of potentially bioactive 2-(alkylamino/amino)-3-arylquinazolin-4(3H)-one analogues from 2-iodophenylcarbodiimides employing amines as nucleophiles and oxalic acid as an ex-situ CO alternative. Various cyclic/acyclic primary and secondary amines were employed and selectively produced substituted 2-(alkylamino)-3-arylquinazolin-4(3H)-ones in good to excellent yields. In addition, we extended the developed strategy to fix two ammonium carbamate and oxalic acid as gaseous NH 3 and CO sources respectively, for the synthesis of 2-amino-3-arylquinazolin-4(3H)-one derivatives. Furthermore, gram scale applicability, diverse substrate scope and high recyclability of the Pd@PS catalyst were the major achievements of the developed protocol.