The Vulvar Immunohistochemical Panel (VIP) Project: Molecular Profiles of Vulvar Squamous Cell Carcinoma.
Giorgia GarganeseFrediano InzaniSimona Maria FragomeniGiulia MantovaniLuigi Della CorteAlessia PiermatteiAngela SantoroGiuseppe AngelicoLuciano GiacòGiacomo CorradoAnna FagottiGian Franco ZannoniGiovanni ScambiaPublished in: Cancers (2021)
Our results support a potential role of immune checkpoint inhibitors and anti-VEGF and anti-EGFR drugs especially in patients with worse prognosis (metastatic, HPV-independent). A panel including EGFR, VEGF, PDL1, p16, and p53 might be performed routinely in primary tumor and repeated in case of lymph node metastases to identify changes in marker expression.
Keyphrases
- small cell lung cancer
- squamous cell carcinoma
- lymph node
- sentinel lymph node
- epidermal growth factor receptor
- vascular endothelial growth factor
- tyrosine kinase
- endothelial cells
- poor prognosis
- quality improvement
- neoadjuvant chemotherapy
- human health
- early stage
- single molecule
- long non coding rna
- rectal cancer
- climate change