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Antimicrobial peptides in hidradenitis suppurativa: a systematic review.

Yiqiu YaoJ W FrewSimon Francis ThomsenHans Christian Ring
Published in: The British journal of dermatology (2021)
This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies varied, the included studies indicate a consistent overexpression of human β-defensin (hBD)-2, S100A7, S100A8 and S100A9 at both the mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional and nonlesional HS skin.
Keyphrases
  • case control
  • hidradenitis suppurativa
  • endothelial cells
  • binding protein
  • poor prognosis
  • induced pluripotent stem cells
  • soft tissue