Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway.
Chuqing LiXia LiuJiali LiJia LaiJingyao SuBing ZhuBuyun GaoYinghua LiMingqi ZhaoPublished in: Nutrients (2024)
Adenovirus (HAdV) can cause severe respiratory infections in children and immunocompromised patients. There is a lack of specific therapeutic drugs for HAdV infection, and the study of anti-adenoviral drugs has far-reaching clinical implications. Elemental selenium can play a specific role as an antioxidant in the human immune cycle by non-specifically binding to the amino acid methionine in body proteins. Methods: The antiviral mechanism of selenomethionine was explored by measuring cell membrane status, intracellular DNA status, cytokine secretion, mitochondrial membrane potential, and ROS production. Conclusions: Selenomethionine improved the regulation of ROS-mediated apoptosis by modulating the expression of Jak1/2, STAT3, and BCL-XL, which led to the inhibition of apoptosis. It is anticipated that selenomethionine will offer a new anti-adenoviral therapeutic alternative.
Keyphrases
- induced apoptosis
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- cell death
- reactive oxygen species
- dna damage
- end stage renal disease
- amino acid
- chronic kidney disease
- endothelial cells
- poor prognosis
- pi k akt
- epithelial mesenchymal transition
- ejection fraction
- young adults
- cell cycle arrest
- early onset
- cell free
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- intensive care unit
- acute respiratory distress syndrome
- cell proliferation
- nucleic acid
- respiratory failure
- extracorporeal membrane oxygenation