Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma.
Abhishek TripathiEdwin LinWanling XieAbdallah FlaifelJohn A SteinharterEmily N Stern GatofGabrielle BouchardJustin H FleischerNieves Martinez-ChanzaConnor GrayCharlene MantiaLinda ThompsonXiao X WeiMarios GiannakisBradley A McGregorToni K ChoueiriArchana M AgarwalDavid F McDermottSabina SignorettiLauren C HarshmanPublished in: Journal for immunotherapy of cancer (2021)
High CD73 expression portends significantly worse survival outcomes independent of stage and grade. Our findings provide compelling support for targeting the immunosuppressive and proangiogenic CD73-adenosine pathway in RCC.