Safety and efficacy of pimecrolimus versus vehicle for the treatment of atopic dermatitis in adults and paediatric population: a systematic review and meta-analysis.
Sareema E AkhtarSaad ShakilSabeeh K FarooquiTarek KhedroAhmad L AlzufairiMuhammad A NiazSaifullah SyedRiaz JiffryAbdulla K AlsubaiAbdullah AlmesriHebatalla IsmailKashif A KhanAhmed Al-HindawiHussein K AliTimothy FalodunAysa TabassiAylin TabassiTalal AlmasPublished in: Annals of medicine and surgery (2012) (2023)
Our meta-analysis showed that pimecrolimus 1% is more effective than vehicle, although the safety profile remains inconclusive. Pimecrolimus reduced the Investigator's Global Assessment score, Eczema Area and Severity Index score, and severity of pruritus when compared to its vehicle, indicating a higher efficacy profile. This is one of the first meta-analyses to assess the efficacy and safety profile of pimecrolimus 1% against a vehicle and may assist physicians in making informed decisions.