Aerobic exercise promotes the functions of brown adipose tissue in obese mice via a mechanism involving COX2 in the VEGF signaling pathway.
Pengyu FuRongxin ZhuJie JiaYang HuChengjun WuPawel CieszczykHans-Christer HolmbergLijing GongPublished in: Nutrition & metabolism (2021)
In mice with HFD-induced obesity, four weeks of aerobic exercise elevated BAT mass and increased the expression of genes related to glycolipid metabolism and anti-inflammatory processes. Several pathways are involved, with COX2 in the VEGF signaling pathway playing a key role.
Keyphrases
- signaling pathway
- high fat diet induced
- adipose tissue
- insulin resistance
- high fat diet
- vascular endothelial growth factor
- endothelial cells
- pi k akt
- anti inflammatory
- high glucose
- epithelial mesenchymal transition
- poor prognosis
- metabolic syndrome
- induced apoptosis
- weight loss
- type diabetes
- diabetic rats
- genome wide
- drug induced
- skeletal muscle
- endoplasmic reticulum stress
- binding protein
- physical activity
- transcription factor
- genome wide analysis