PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.

Shi-Zhe ZhangXiao-Dong ZhuLong-Hai FengXiao-Long LiXue-Feng LiuHui-Chuan SunZhao-You Tang

Published in: Experimental hematology & oncology (2021)

PCSK9 expression level in HCC is an indicator of poor prognosis for patients with HCC. FASN-mediated anti-apoptosis plays an important role in PCSK9-induced HCC progression.

Keyphrases

poor prognosis
long non coding rna
low density lipoprotein
oxidative stress
diabetic rats
high glucose
endoplasmic reticulum stress
signaling pathway
cell proliferation
cell cycle arrest
endothelial cells