Enhanced proliferation and differentiation of human mesenchymal stem cells in the gravity-controlled environment.
Tadashi Nakaji-HirabayashiKazuaki MatsumuraReiichi IshiharaTatsuya IshiguroHiromitsu NasuMasatsugu KannoShunji IchidaToshikatsu HatashimaPublished in: Artificial organs (2022)
Our results indicate that hMSC proliferation and selective differentiation into specific cell lineages could be promoted under microgravity or hypergravity conditions, suggesting that cell culture in the gravity-controlled environment is a useful method to obtain cell preparations for potential clinical applications.