A Blunted GPR183/Oxysterol Axis During Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung During Mycobacterium tuberculosis Infection.

Minh Dao NgoStacey BartlettHelle Bielefeldt-OhmannCheng Xiang FooRoma SinhaBuddhika Jayakody ArachchigeSarah ReedThomas Mandrup-PoulsenMette Marie RosenkildeKatharina Ronacher

Published in: The Journal of infectious diseases (2022)

Taken together, we demonstrate a requirement of the GPR183/oxysterol axis for positioning of macrophages to the site of infection and add an explanation to more severe TB in diabetes patients.

Keyphrases

mycobacterium tuberculosis
end stage renal disease
ejection fraction
type diabetes
newly diagnosed
chronic kidney disease
cardiovascular disease
fatty acid
glycemic control
pulmonary tuberculosis
patient reported outcomes
metabolic syndrome
weight loss