MCT4 blockade increases the efficacy of immune checkpoint blockade.
Nathalie BablSonja-Maria DeckingFlorian VollMichael AlthammerAda Sala-HojmanRoberta FerrettiClarissa KorfChristian SchmidlLisa SchmidleithnerBenedikt NerbCarina MatosGudrun E KoehlPeter J SiskaChristina BrussFabian KellermeierKatja DettmerPeter J OefnerMarvin WichlandInes UgeleChristopher BohrWolfgang HerrShivapriya RamaswamyTimo HeinrichChristian HerhausMarina KreutzKathrin RennerPublished in: Journal for immunotherapy of cancer (2023)
These findings demonstrate that single MCT4 inhibition represents a novel therapeutic approach to reverse lactic-acid driven immunosuppression and might be suitable to improve ICB efficacy.
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