UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells.
Jhih-Yun HoHsin-Ying LuHsing-Hsien ChengYu-Chieh KuoYu-Lin Amy LeeChia-Hsiung ChengPublished in: Cellular oncology (Dordrecht) (2021)
Higher UBE2S expression in lung adenocarcinomas may lead to increased binding with IκBα to activate NF-κB signaling and promote adenocarcinoma cell metastasis. UBE2S may serve as a potential therapeutic target for lung adenocarcinomas.
Keyphrases
- signaling pathway
- induced apoptosis
- lps induced
- pi k akt
- binding protein
- cell cycle arrest
- oxidative stress
- poor prognosis
- nuclear factor
- squamous cell carcinoma
- single cell
- dna binding
- inflammatory response
- squamous cell
- radiation therapy
- toll like receptor
- locally advanced
- immune response
- endoplasmic reticulum stress
- mesenchymal stem cells
- transcription factor
- long non coding rna
- climate change