Correlation of CpG methylation of the Pdcd1 gene with PD-1 expression on CD8+ T cells and medical laboratory indicators in chronic hepatitis B infection.
Lin JiaoJie ChenXiaojuan WuBei CaiZhenzhen SuLanlan WangPublished in: The journal of gene medicine (2020)
The results of the present study suggest that Pdcd1 methylation is correlated with PD-1 expression on CD8+ T cells and correlated with HBsAg and alanine aminotransferase. The results may provide new ideas regarding anti-PD-1 inhibitors, and epigenetic regulators such as demethylation inhibitors could represent more successful therapeutic strategies in hepatitis B infection patients.
Keyphrases
- dna methylation
- poor prognosis
- genome wide
- hepatitis b virus
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- gene expression
- healthcare
- binding protein
- prognostic factors
- peritoneal dialysis
- transcription factor
- patient reported outcomes
- long non coding rna
- patient reported
- liver fibrosis