Repetitive Bleomycin-Based Electrochemotherapy Improves Antitumor Effectiveness in 3D Tumor Models of Conjunctival Melanoma.

Joana HeinzelmannSabine HechtAlexander Ruben VogtUdo SieboltsPeter KaatzschArne Viestenz

Published in: Journal of clinical medicine (2023)

Repetitive ECT application effectively induces cytotoxic effects in CM spheroids by inducing apoptosis, inhibiting proliferation and decreasing the percentage of surviving tumor cells. Thus, repetitive ECT results in improved antitumor effectiveness in CM and could be an alternative therapy option.

Keyphrases

high frequency
randomized controlled trial
systematic review
signaling pathway
oxidative stress
endoplasmic reticulum stress
cell death
cell cycle arrest
mesenchymal stem cells
bone marrow
pi k akt