The neuropeptide cycloprolylglycine produces antidepressant-like effect and enhances BDNF gene expression in the mice cortex.

Aliya A Abdullina Ekaterina V VasilevaElizabeth A KulikovaVladimir S NaumenkoAlexandra V PlyusninaTatyana A GudashevaGeorgy I KovalevSergei B Seredenin

Published in: Journal of psychopharmacology (Oxford, England) (2022)

Our findings extend the evidence for the effectiveness of CPG to reduce depressive-like behaviors. The antidepressant-like effect of CPG is mediated, as least in part, by BDNF-dependent mechanism. The exact mechanism remains to be elucidated, and further studies are warranted.

Keyphrases

dna methylation
gene expression
major depressive disorder
stress induced
bipolar disorder
randomized controlled trial
systematic review
high fat diet induced
functional connectivity
density functional theory