Amycolasporins and Dibenzoyls from Lichen-Associated Amycolatopsis hippodromi and Their Antibacterial and Anti-inflammatory Activities.
Ying JinNuerbiye AobulikasimuZengguang ZhangChengbin LiuBixuan CaoBin LinPeipei GuanYu MuYi JiangLi HanXue-Shi HuangPublished in: Journal of natural products (2020)
Eleven metabolites, six echinosporins (1-6), four dibenzoyls (7-10), and an aromatic compound (11), were isolated from the fermentation broth of lichen-associated Amycolatopsis hippodromi. The structures of the new compounds (1-5, 8-11) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra. Amycolasporins A-C (1-3) demonstrated antibacterial activities against Bacillus subtilis, Staphylococcus aureus, and Escherichia coli with MIC values of 25 or 100 μg/mL. Amycolasporin C (3) and the known dibenzoyl (7) attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells in a dose-dependent manner.
Keyphrases
- nitric oxide synthase
- lps induced
- anti inflammatory
- bacillus subtilis
- nitric oxide
- escherichia coli
- staphylococcus aureus
- inflammatory response
- induced apoptosis
- poor prognosis
- silver nanoparticles
- biofilm formation
- cell cycle arrest
- electronic health record
- high resolution
- amino acid
- big data
- essential oil
- oxidative stress
- signaling pathway
- endoplasmic reticulum stress
- cystic fibrosis
- machine learning
- cell proliferation
- saccharomyces cerevisiae
- long non coding rna
- pseudomonas aeruginosa
- binding protein
- mass spectrometry
- data analysis
- multidrug resistant