PITX2 Knockout Induces Key Findings of Electrical Remodeling as Seen in Persistent Atrial Fibrillation.
Carl SchulzMarc D LemoineGiulia MeariniJussi T KoivumäkiJascha SaniEdzard SchwedhelmPaulus F KirchhofAmer GhalawinjiMonika StollArne HansenThomas EschenhagenTorsten ChristPublished in: Circulation. Arrhythmia and electrophysiology (2023)
Complete PITX2 deficiency in human induced pluripotent stem cell-derived atrial cardiomyocytes recapitulates some findings of electrical remodeling of atrial fibrillation in the absence of fast beating, indicating that these abnormalities could be primary consequences of lower PITX2 levels.
Keyphrases
- atrial fibrillation
- catheter ablation
- high glucose
- left atrial
- endothelial cells
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- diabetic rats
- percutaneous coronary intervention
- induced pluripotent stem cells
- mitral valve
- replacement therapy
- pluripotent stem cells
- acute coronary syndrome
- coronary artery disease
- left ventricular