Anti-diabetic effect of a novel oligosaccharide isolated from Rosa canina via modulation of DNA methylation in Streptozotocin-diabetic rats.

Gholamreza BahramiSoraya SajadimajdBahareh MohammadiRazieh HatamiShahram MiraghaeeSamira KeshavarziMozafar KhazaeiSeyed Hamid Madani

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2020)

Results revealed that DNA methylation plays a causal role in the effectiveness of the isolated OF. Furthermore, the possible regenerative potential of oligosaccharide in diabetic rats may have contributed to the modulation of DNA methylation.

Keyphrases

diabetic rats
dna methylation
oxidative stress
genome wide
gene expression
stem cells
type diabetes
randomized controlled trial
mesenchymal stem cells
copy number
cell therapy
single cell
wound healing
adipose tissue
bone marrow
risk assessment
metabolic syndrome
human health
insulin resistance