KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer.

Jing Yang Lin Jin Hong Sun Kim Feng Tian Zhujun Yi Karan Bedi Mats Ljungman Marina Pasca Di Magliano Howard C Crawford Jiaqi Shi

Published in: Cancer research (2022)

KDM6A loss in pancreatic cancer cells alters the immune microenvironment by increasing CXCL1 secretion and neutrophil recruitment, providing a rationale for targeting the CXCL1-CXCR2 signaling axis in tumors with low KDM6A.

Keyphrases

stem cells
clinical trial