Does CSF1 overexpression or rearrangement influence biological behaviour in tenosynovial giant cell tumours of the knee?

Monique Josephine MastboomDaisy M HoekJudith V M G BovéeMichiel A J van de SandeKároly Szuhai

Published in: Histopathology (2018)

In diagnosing TGCT, CSF1 mRNA-ISH, in combination with CSF1 split-apart FISH using digital correlative microscopy, is an auxiliary diagnostic tool to identify rarely occurring neoplastic cells. This combined approach allowed us to detect CSF1 rearrangement in 76% of the TGCT cases. Neither CSF1 expression nor presence of CSF1 rearrangement could be associated with the difference in biological behaviour of TGCT.

Keyphrases

giant cell
cerebrospinal fluid
poor prognosis
induced apoptosis
high resolution
total knee arthroplasty
oxidative stress
long non coding rna