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Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.

Jack H BrelstaffMatthew MasonTaxiarchis KatsinelosWilliam A McEwanBernardino GhettiMaria Grazia SpillantiniMaria Grazia Spillantini
Published in: Science advances (2021)
[Figure: see text].
Keyphrases
  • cerebrospinal fluid
  • spinal cord
  • inflammatory response
  • neuropathic pain
  • smoking cessation
  • spinal cord injury