William A McEwan

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 10

Top Venues

Science (New York, N.Y.)

The Journal of biological chemistry

Proceedings of the National Academy of Sciences of the United States of America

Science advances

University of Cambridge

University of Glasgow (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge

United Kingdom

Sir Henry Dale Fellow :: Department of Clinical Neurosciences

Education History

University of Glasgow - Sep 01 2009

United Kingdom

PHD :: Faculty of Veterinary Medicine

Publications

Jonathan Benn, Shi Cheng, Sophie Keeling, Annabel E Smith, Marina J Vaysburd, Dorothea Böken, Lauren V C Miller, Taxiarchis Katsinelos, Catarina Franco, Elian Dupré, Clément Danis, Isabelle Landrieu, Luc Buee, David Klenerman, Leo C James, William A McEwan
Aggregate-selective removal of pathological tau by clustering-activated degraders. Science (New York, N.Y.) 385 (6712) (2024)
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri Aastedatter Sakya, Sophie A I Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Christopher Green, Lise R Skov, Sanne Simone Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James Benedict Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.) 379 (6639) (2023)
Sophie A I Sanford, Lauren V C Miller, Marina Vaysburd, Sophie Keeling, Benjamin J Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C James, William A McEwan
The type-I interferon response potentiates seeded tau aggregation and exacerbates tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Aamir S Mukadam, Lauren V C Miller, Annabel E Smith, Marina Vaysburd, Siri Aastedatter Sakya, Sophie A I Sanford, Sophie Keeling, Benjamin J Tuck, Taxiarchis Katsinelos, Christopher Green, Lise R Skov, Sanne Simone Kaalund, Stian Foss, Keith Mayes, Kevin O'Connell, Mark Wing, Claire Knox, Jessica Banbury, Edward Avezov, James Benedict Rowe, Michel Goedert, Jan Terje Andersen, Leo C James, William A McEwan
Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science (New York, N.Y.) 379 (6639) (2023)
Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A Krawczyk, Alexandra K Davies, Julia Patricia Schessner, Reejuana Parveen, Benjamin J Tuck, William A McEwan, Georg H H Borner, Patrycja Kozik
Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells. Science (New York, N.Y.) 380 (6651) (2023)
Jack H Brelstaff, Matthew Mason, Taxiarchis Katsinelos, William A McEwan, Bernardino Ghetti, Maria Grazia Spillantini, Maria Grazia Spillantini
Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates. Science advances 7 (43) (2021)
Jingwei Zeng, Ana Filipa Santos, Aamir S Mukadam, Mariana Osswald, David A Jacques, Claire F Dickson, Stephen H McLaughlin, Christopher M Johnson, Leo Kiss, Jakub Luptak, Nadine Renner, Marina Vaysburd, William A McEwan, Eurico Morais-de-Sá, Dean Clift, Leo C James
Target-induced clustering activates Trim-Away of pathogens and proteins. Nature structural & molecular biology 28 (3) (2021)
Eliana Nachman, Anne S Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A McEwan, Thomas R Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Krammer
Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. The Journal of biological chemistry 295 (28) (2020)
Donna L Mallery, Chantal L Márquez, William A McEwan, Claire F Dickson, David A Jacques, Madhanagopal Anandapadamanaban, Katsiaryna Bichel, Gregory J Towers, Adolfo Saiardi, Till Boecking, Leo C James
IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis. eLife 7 (2018)
William A McEwan, Benjamin Falcon, Marina Vaysburd, Dean Clift, Adrian L Oblak, Bernardino Ghetti, Michel Goedert, Leo C James
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proceedings of the National Academy of Sciences of the United States of America 114 (3) (2017)

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Publication Activity (10 Years)

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William A McEwan