Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twins.

Nora AlrumayyanDrew SlauenwhiteSarah M McAlpineSarah RobertsThomas B IssekutzAdam M HuberZaiping LiuBeata Derfalvi

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2022)

cells, decreased CTLA-4 expression, and defects in memory B cells may be a feature of immune dysregulation associated with PD; however, a larger sample size is required to validate these findings. The high IL-18 plasma levels suggest underlying autoinflammatory processes.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
machine learning
working memory
cell death
oxidative stress
signaling pathway
replacement therapy