Successful use of next generation genomic sequencing (NGS)-directed therapy of clear cell carcinoma of the ovary (CCCO) with trametinib and metformin in a patient with chemotherapy-refractory disease.
Michael P CastroBradford P WhitcombDeborah A ZajchowskiRobert L ColemanPublished in: Gynecologic oncology research and practice (2015)
The case highlights the utility of precision medicine combining individual molecular diagnosis with rational therapeutic intervention with targeted agents.