Identification and validation of COL6A1 as a novel target for tumor electric field therapy in glioblastoma.

Junyi ChenYuyang LiuJinxin Lan Hongyu LiuQingyun TangZe LiXiaoguang QiuWentao HuJiaxin XieYaping FengLilin QinXin ZhangJialin LiuLing Chen

Published in: CNS neuroscience & therapeutics (2024)

TEFT could remodel the ECM of GBM cells by downregulating COL6A1 expression and inhibiting focal adhesion pathway. COL6A1 could interact with ITGA5 and activate the focal adhesion pathway, suggesting that it might be a potential therapeutic target mediating the antitumor effects of TEFT.

Keyphrases

induced apoptosis
poor prognosis
biofilm formation
cell cycle arrest
signaling pathway
cell migration
oxidative stress
pseudomonas aeruginosa
endoplasmic reticulum stress
binding protein
cystic fibrosis
risk assessment
human health
extracellular matrix
long non coding rna
climate change
cell therapy
pi k akt