Co-microencapsulation of human umbilical cord-derived mesenchymal stem and pancreatic islet-derived insulin producing cells in experimental type 1 diabetes.
Pia MontanucciTeresa PescaraAlessia GrecoGiulia LeonardiLuigi MariniGiuseppe BastaRiccardo CalafiorePublished in: Diabetes/metabolism research and reviews (2020)
We have gathered preliminary evidence that the two adult stem cell types within AG microcapsules, may synergistically promote tracer insulin production, while "freezing" the autoimmune disease process, and help reversal of the recent onset hyperglycemia in a spontaneous, autoimmune rodent model of diabetes, the NOD mouse, with no need for pharmacologic immunosuppression.
Keyphrases
- type diabetes
- umbilical cord
- glycemic control
- stem cells
- mesenchymal stem cells
- induced apoptosis
- multiple sclerosis
- endothelial cells
- cardiovascular disease
- bone marrow
- insulin resistance
- cell cycle arrest
- drug induced
- quantum dots
- induced pluripotent stem cells
- pluripotent stem cells
- pet imaging
- adipose tissue
- oxidative stress
- positron emission tomography
- signaling pathway
- cell therapy
- young adults
- highly efficient