Synergistic Effects between Ambient Air Pollution and Second-Hand Smoke on Inflammatory Skin Diseases in Chinese Adolescents.

Atopic dermatitis (AD), chronic hand eczema (CHE), and urticaria are common inflammatory skin diseases among adolescents and associated with air quality. However, the synergistic effects of ambient air pollution and second-hand smoke (SHS) have been unclear. We conducted a cross-sectional study including 20,138 Chinese college students where dermatological examinations and a questionnaire survey were carried out. A generalized linear mixed model was applied for the association between individualized exposure of O 3 , CO, NO 2 , SO 2 , PM 2.5 , and PM 10 and the prevalence of inflammatory skin diseases. Interactions between air pollutants and SHS were analyzed. As a result, CO, NO 2 , SO 2 , PM 2.5 , and PM 10 were positively correlated with the prevalence of AD, CHE, and urticaria. Higher frequency of SHS exposure contributed to increased probabilities of AD ( p = 0.042), CHE ( p < 0.001), and urticaria ( p = 0.002). Of note, CO (OR: 2.57 (1.16-5.69) in third quartile) and NO 2 (OR: 2.38 (1.07-5.27) in third quartile) had positive interactions with SHS for AD, and PM 2.5 synergized with SHS for CHE (OR: 2.25 (1.22-4.15) for second quartile). Subgroup analyses agreed with the synergistic results. In conclusion, SHS and ambient air pollution are both associated with inflammatory skin diseases, and they have a synergistic effect on the prevalence of AD and CHE.