Glycodeoxycholic acid inhibits primary bile acid synthesis with minor effects on glucose- and lipid homeostasis in humans.
Emma C E MeessenSoumia MajaitÜmran AySteven W Olde DaminkJohannes A RomijnJens J HolstBolette HartmannFolkert KuipersMax NieuwdorpFrank G SchaapAlbert K GroenE Marleen KemperMaarten R SoetersPublished in: The Journal of clinical endocrinology and metabolism (2024)
GDCA administration leads to elevated FGF19 levels and effectively inhibits primary bile acid synthesis, supporting therapy compliance and its effectiveness. However, effects on lipid, glucose- and energy metabolism were minimal, indicating that expanding the pool of this relatively hydrophobic bile acid does not impact energy metabolism in healthy subjects.