Cyrene™ as a Neoteric Bio-Based Solvent for Catalyst-Free Microwave-Assisted Construction of Diverse Bipyridine Analogues for Heavy-Metal Sensing.
Ramuel John Inductivo TamargoPeter Yuosef M RubioSonaimuthu MohandossJae-Jin ShimYong Rok LeePublished in: ChemSusChem (2021)
An environment-friendly synthetic protocol was developed to access polyfunctionalized bipyridines from readily available amines, chromone-3-carboxaldehydes, and pyridinylacetonitriles under catalyst- and additive-free conditions using the bio-renewable neoteric solvent dihydrolevoglucosenone (Cyrene™). In this strategy, amines served as both a mild-base promoter and a substrate. In addition, water was the only by-product of this reaction. This multi-component protocol provided highly diverse 2,3-, 3,3-, and 3,4-bipyridines in good-to-excellent yields. Operational simplicity, short reaction time, excellent atom economy, and easily obtainable substrates are among the features of this microwave-assisted synthesis. Additionally, the compounds synthesized via this method have demonstrated the ability to detect heavy metals, specifically mercury(II), copper(II), and iron (III) ions.
Keyphrases
- heavy metals
- ionic liquid
- risk assessment
- health risk assessment
- room temperature
- randomized controlled trial
- health risk
- reduced graphene oxide
- electron transfer
- sewage sludge
- highly efficient
- dna methylation
- carbon dioxide
- gene expression
- metal organic framework
- transcription factor
- molecular dynamics
- molecular docking
- oxide nanoparticles
- visible light
- molecular dynamics simulations
- iron deficiency
- amino acid