Development of a human heart-sized perfusion system for metabolic imaging studies using hyperpolarized [1-13 C]pyruvate MRI.
Christian Østergaard MariagerEsben Søvsø Szocska HansenSabrina Kahina BechHans EiskjaerPeter Fast NielsenSteffen RinggaardHans-Henrik KimoseChristoffer LaustsenPublished in: Magnetic resonance in medicine (2020)
We investigated the metabolic and functional status of machine-perfused porcine hearts. Utilizing hyperpolarized methodology to acquire detailed myocardial metabolic information-in combination with already established MR methods for cardiac investigation-provides a powerful tool to aid the progress of donor heart preservation.
Keyphrases
- contrast enhanced
- heart failure
- left ventricular
- endothelial cells
- magnetic resonance imaging
- atrial fibrillation
- magnetic resonance
- deep learning
- healthcare
- induced pluripotent stem cells
- mass spectrometry
- health information
- pluripotent stem cells
- diffusion weighted imaging
- social media
- atomic force microscopy
- case control
- photodynamic therapy