The NGF/TrKA pathway enhances analgesia in an experimental mice model of bone cancer pain by increasing membrane levels of δ-opioid receptors.
Bu-Fan KanXing-Yun LiuMing-Ming HanCheng-Wei YangXia ZhuYan JinDi WangXiang HuangWen-Jie WuTong FuFang KangZhi ZhangJuan LiPublished in: Anesthesiology (2023)
Activation of mDOR produce analgesia that is dependent on the upregulation of the NGF/TrKA pathway by increasing mDOR levels under conditons of BCP in mice.
Keyphrases
- pain management
- chronic pain
- high fat diet induced
- growth factor
- postoperative pain
- papillary thyroid
- ultrasound guided
- poor prognosis
- cell proliferation
- signaling pathway
- bone mineral density
- squamous cell
- neuropathic pain
- squamous cell carcinoma
- type diabetes
- spinal cord
- wild type
- long non coding rna
- soft tissue
- body composition
- adipose tissue
- skeletal muscle
- bone loss