Login / Signup

Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria.

Christopher VennardTemitope OropoHerman O Sintim
Published in: Journal of medicinal chemistry (2023)
Vancomycin-like drugs target peptidoglycan (PG) via binding to C-terminal d-Ala-d-Ala dipeptide. An engineered vancomycin has enhanced affinity for the PG stem peptide, due to probable interactions with a third residue, meso -diaminopimelic acid, in the PG. This engineered vancomycin displays enhanced killing of mycobacteria.
Keyphrases
  • methicillin resistant staphylococcus aureus
  • mycobacterium tuberculosis
  • staphylococcus aureus
  • cell wall
  • emergency department
  • bacillus subtilis
  • human immunodeficiency virus
  • electronic health record