SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

Manuel RoggJasmin I MaierRobert DotzauerNadine ArteltOliver KretzMartin HelmstädterAhmed AbedAlena SammarcoAugust SigleDominik SellungPatrick DinseKaroline ReicheMako Yasuda-YamaharaMartin L BiniossekGerd WalzMartin WernerNicole EndlichOliver SchillingTobias B HuberChristoph Schell

Published in: Journal of the American Society of Nephrology : JASN (2021)

SRGAP1, a podocyte-specific RhoGAP, controls podocyte foot-process architecture by limiting the activity of protrusive, branched actin networks. Therefore, elucidating the complex regulatory small Rho GTPase affinity network points to novel targets for potentially precise intervention in glomerular diseases.

Keyphrases

diabetic nephropathy
high glucose
endothelial cells
randomized controlled trial
protein kinase
smooth muscle
transcription factor
mass spectrometry