Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro.

Jakob SiedleckiChristian WertheimerArmin WolfRaffael LieglClaudia PriglingerSiegfried PriglingerKirsten Eibl-Lindner

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2017)

Axitinib inhibits angiogenesis in endothelial cells and pericytes via VEGFR and PDGFR modulation in vitro. Further studies are needed to elucidate whether axitinib may also improve therapy of CNV in AMD in vivo by interference with pericyte stabilization of pathological vessels.

Keyphrases

endothelial cells
vascular endothelial growth factor
age related macular degeneration
metastatic renal cell carcinoma
high glucose
blood brain barrier
smooth muscle
vascular smooth muscle cells
mesenchymal stem cells
bone marrow
cell therapy
pluripotent stem cells
wound healing