Crucial role of fatty acid oxidation in asthmatic bronchial smooth muscle remodelling.

Pauline EstevesLandry BlancAlexis CelleIsabelle DupinElise MauratNivea AmoedoGuillaume CardouatOlga OusovaLara GalesFloriant BellvertHugues BegueretMatthieu Thumerel Jean-William DupuyNicolas DesbenoitRoger MarthanPierre-Olivier GirodetRodrigue RossignolPatrick BergerThomas Trian

Published in: The European respiratory journal (2021)

This study demonstrates a metabolic switch towards mitochondrial β-oxidation in asthmatic BSM and identifies fatty acid metabolism as a new key target to reduce BSM remodelling in asthma.

Keyphrases

fatty acid
smooth muscle
lung function
hydrogen peroxide
chronic obstructive pulmonary disease
oxidative stress
air pollution
gene expression
nitric oxide