A pilot phase Ib/II study of whole-lung low dose radiation therapy (LDRT) for the treatment of severe COVID-19 pneumonia: First experience from Africa.
Mansoor N SalehKarishma SharmaJasmit ShahFarrok KarsanAngela WaweruMartin MusumbiReena ShahShahin SayedInnocent AbayoNoureen KarimiStacey GondiSehrish RupaniGrace KiratheHeldah AmariatiPublished in: PloS one (2022)
LDRT was feasible, safe and shows promise in the management of severe COVID-19 pneumonia including in patients progressing on conventional systemic treatment. Additional phase II trials are warranted to identify patients most likely to benefit from LDRT.
Keyphrases
- end stage renal disease
- low dose
- radiation therapy
- coronavirus disease
- chronic kidney disease
- sars cov
- ejection fraction
- newly diagnosed
- phase ii
- clinical trial
- peritoneal dialysis
- prognostic factors
- early onset
- randomized controlled trial
- high dose
- machine learning
- drug induced
- deep learning
- patient reported outcomes
- combination therapy
- double blind
- placebo controlled