Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low-avoidance) and resistance (Roman high-avoidance) to stress-induced depression.

M Pina SerraLaura PoddigheMarianna BoiFrancesco SannaM Antonietta PiluduM Giuseppa CordaOsvaldo GiorgiMarina Quartu

Published in: Brain and behavior (2017)

These findings support the hypothesis that a reduced BDNF/trkB signaling in the hippocampus of RLA versus RHA rats may contribute to their more pronounced vulnerability to stress-induced depression.

Keyphrases

stress induced
climate change
depressive symptoms
poor prognosis
sleep quality
cerebral ischemia
cognitive impairment
prefrontal cortex
oxidative stress
gene expression
binding protein
long non coding rna
blood brain barrier