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Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies.

Roberto SansoneJavier I OttavianiAna Rodriguez-MateosYvonne HeinenDorina NoskeJeremy P SpencerAlan CrozierMarc W MerxMalte KelmHagen SchroeterChristian Heiss
Published in: The American journal of clinical nutrition (2016)
A substantial interaction between cocoa flavanols and methylxanthines exists at the level of absorption, in which the methylxanthines mediate an increased plasma concentration of (-)-epicatechin metabolites that coincides with enhanced vascular effects commonly ascribed to cocoa flavanol intake. This trial was registered at clinicaltrials.gov as NCT02149238.
Keyphrases
  • phase iii
  • phase ii
  • open label
  • double blind
  • clinical trial
  • ms ms
  • placebo controlled
  • study protocol
  • randomized controlled trial
  • case control
  • weight gain
  • body mass index