Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis.
Ana Belén CrujeirasSonsoles MorcilloAngel Diaz-LagaresJuan SandovalDaniel Castellano-CastilloEsperanza TorresDavid HervasSebastian MoranManel EstellerManuel Macias-GonzálezFelipe F CasanuevaFrancisco J TinahonesPublished in: International journal of obesity (2005) (2018)
The present study identifies a potential epigenome mark of obesity-related CRC that could be useful for precision medicine in the management of this disease taking into account adiposity as a relevant risk factor.
Keyphrases
- dna methylation
- genome wide
- insulin resistance
- weight gain
- metabolic syndrome
- weight loss
- type diabetes
- high fat diet induced
- gene expression
- endothelial cells
- copy number
- risk factors
- adipose tissue
- skeletal muscle
- induced pluripotent stem cells
- human health
- physical activity
- risk assessment
- pluripotent stem cells
- bioinformatics analysis