CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer.

Siyuan ZengBin LanXiaofan RenShuman ZhangDaniel SchreyerMarkus EcksteinHai YangNathalie Britzen-LaurentAndreas DahlDebabrata MukhopadhyayDavid ChangIsabella KutschickSusanne PfefferPeter BaileyAndrew BiankinRobert GrützmannChristian Pilarsky

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our findings support the application of CRISPR-Cas9 screening in identifying novel therapeutic targets and suggest new strategies for overcoming chemoresistance in pancreatic cancer.

Keyphrases

crispr cas
genome editing
drug resistant
cell cycle
locally advanced
cell proliferation