Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial.

Kait F AlLaura J CravenShaeley GibbonsSeema Nair ParvathyAna Christina WingChantelle GrafKate A ParhamSteven M KerfootHannah WilcoxJeremy P BurtonMarcelo KremenchutzkySarah A MorrowCourtney CasserlyJon MeddingsManas SharmaMichael S Silverman

Published in: Multiple sclerosis journal - experimental, translational and clinical (2022)

FMT was safe and tolerable in this cohort of RRMS patients, may improve elevated small intestinal permeability, and has the potential to enrich for an MS-protective microbiota. Further studies with longer follow-up and larger sample sizes are required to determine if FMT is a suitable therapy for MS.

Keyphrases

randomized controlled trial
mass spectrometry
end stage renal disease
multiple sclerosis
study protocol
ms ms
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
clinical trial
endothelial cells
human health
mesenchymal stem cells