Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial.
Kait F AlLaura J CravenShaeley GibbonsSeema Nair ParvathyAna Christina WingChantelle GrafKate A ParhamSteven M KerfootHannah WilcoxJeremy P BurtonMarcelo KremenchutzkySarah A MorrowCourtney CasserlyJon MeddingsManas SharmaMichael S SilvermanPublished in: Multiple sclerosis journal - experimental, translational and clinical (2022)
FMT was safe and tolerable in this cohort of RRMS patients, may improve elevated small intestinal permeability, and has the potential to enrich for an MS-protective microbiota. Further studies with longer follow-up and larger sample sizes are required to determine if FMT is a suitable therapy for MS.