Allogeneic stem cell transplantation as part of front line therapy for Mantle cell lymphoma.
Simon A RuleGordon CookNigel H RussellAnn HunterStephen RobinsonNick MorleyAnna SuredaPip PatrickLaura Clifton-HadleyToyin AdedayoAmy KirkwoodKarl S PeggsPublished in: British journal of haematology (2018)
Mantle cell lymphoma (MCL) is an aggressive form of non-Hodgkin lymphoma that remains incurable for the majority of patients. Allogeneic stem cell transplantation (alloSCT) produces long-term disease-free remissions for around 30-40% patients, however it is reserved for the treatment of relapsed disease. This study examined the use of front line transplantation for young patients in an attempt to improve outcomes. Twenty-five patients received an alloSCT using BEAM [BCNU (carmustine), etoposide, cytarabine, melphalan)-Campath conditioning following permissive induction therapy from both related and unrelated donors. This was a multi-centre prospective trial. Twenty-four of 25 patients engrafted with no non-relapse mortality events by day 100. With a median follow-up of 60·5 months, there have been six deaths (3 from MCL). The progression-free survival (PFS) and overall survival were 68% and 80% at 2 years and 56% and 76% at 5 years. PFS was very similar for both sibling and unrelated transplants and there was no difference in PFS between patients with respect to remission status prior to transplantation. Nine (38%) patients experienced acute graft-versus-host disease (GVHD) and 14 (58%) experienced chronic GVHD, of which 8 were extensive. Front line alloSCT is feasible but should only be considered for patients at high risk of early progression following conventional therapy.
Keyphrases
- stem cell transplantation
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high dose
- prognostic factors
- stem cells
- cardiovascular disease
- peritoneal dialysis
- randomized controlled trial
- acute myeloid leukemia
- clinical trial
- free survival
- type diabetes
- mesenchymal stem cells
- intensive care unit
- rheumatoid arthritis
- systemic lupus erythematosus
- acute lymphoblastic leukemia
- open label
- diffuse large b cell lymphoma
- liver failure
- allogeneic hematopoietic stem cell transplantation
- insulin resistance
- risk factors
- smoking cessation
- phase iii
- combination therapy
- kidney transplantation