Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer.

Shintaro Kinoshita Midori Ishii Jun Ando Takaharu Kimura Tomoyuki Yamaguchi Sakiko Harada Fumiyuki Takahashi Kazutaka Nakashima Yozo Nakazawa Satoshi Yamazaki Koichi Ohshima Kazuhisa Takahashi Hiromitsu Nakauchi Miki Ando

Published in: Cancer research communications (2024)

This research introduces iPSC-derived rejuvenated GD2-CARTs (GD2-CARrejT) as a novel approach to combat SCLC. Compared with conventional GD2-CARTs, GD2-CARrejTs with reduced TIGIT and PD-1 expression demonstrate robust cytotoxicity against SCLC and would be a promising therapy for SCLC.

Keyphrases

small cell lung cancer
induced apoptosis
poor prognosis
cell cycle arrest
binding protein
brain metastases