CYP1A2 polymorphisms modify the association of habitual coffee consumption with appetite, macronutrient intake, and body mass index: results from an observational cohort and a cross-over randomized study.

Kalliopi G GkouskouGeorgios GeorgiopoulosIoannis M VlastosEvgenia LazouDimitrios ChaniotisTheodore G PapaioannouChristos S MantzorosDespina SanoudouAristides G Eliopoulos

Published in: International journal of obesity (2005) (2021)

CYP1A2 rs762551 polymorphism modifies the association of habitual coffee consumption with BMI, in part by influencing appetite, energy intake and circulating levels of the orexigenic hormone asprosin. This association is more evident in subjects with high genetic predisposition to obesity. ClinicalTrials.gov: registered Clinical Trial NCT04514588.

Keyphrases

body mass index
weight gain
clinical trial
weight loss
type diabetes
insulin resistance
metabolic syndrome
randomized controlled trial
genome wide
gene expression
body weight
high fat diet induced