MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B BrownDaniel J TozerLaurence LoubièreYoung T HongTim D FryerGuy B WilliamsMartin J GravesFranklin I AigbirhioJohn T O'BrienHugh S MarkusPublished in: European stroke journal (2022)
The MINERVA trial aims to test whether minocycline can influence novel pathological processes thought to be involved in SVD progression, and will provide insights into whether central nervous system inflammation in SVD can be therapeutically modulated.